Literature with Zaiput
Scientific articles featuring our separators:
Scientific research articles relating to our multistage extraction platform:
Scientific articles featuring our back pressure regulators:
Liquid-Liquid Separation
Scientific articles featuring our separators:
Yiota-Victoria Phakoukaki, Paul O’Shaughnessy, Panagiota Angeli, Intensified liquid-liquid
extraction of biomolecules using ionic liquids in small channels, Separation and
Purification and Technology, Feb 2022.
David Roura Padrosa and Martina L. Contente, Multi-gram preparation of
cinnamoyl tryptamines as skin whitening agents through a chemo-enzymatic flow process,
Tetrahedron Letters, Dec 2021.
Cecilia Pinna, Piera Anna Martino, Gabriele Meroni, Valerio Massimo Sora, Lucia Tamborini, Sabrina
Dallavalle, Martina L. Contente, and Andrea Pinto, Biocatalyzed Synthesis of Vanillamides and
Evaluation of Their Antimicrobial Activity, J. Agric. Food Chem., Dec
2021.
Francesca Annunziata, Alessandra Guaglio, Paola Conti, Lucia Tamborini and Raffaella Gandolfi, Continuous-flow
stereoselective reduction of prochiral ketones in a whole cell bioreactor with natural deep eutectic
solvents, Green Chemistry, Dec 2021.
Mara Di Filippo and Marcus Baumann, Continuous Flow
Synthesis of Anticancer Drugs, Molecules, Nov 2021.
Francesca Annunziata, Martina L. Contente, Cecilia Pinna, Lucia Tamborini, and Andrea Pinto, Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and
Efficient Production of Their Acetate Esters, Antioxidants, July 2021.
Jinu Joseph John, Tom Van Gerven, Effect of ultrasound on
parallel flow in a microchannel, Chemical Engineering and Processing – Process
Intensification, May 2021.
Itziar Peñafiel, Sebastian C. Cosgrove, Biocatalysis in Flow for Drug Discovery,
Flow Chemistry in Drug Discovery, April 2021.
Dimitrios Tsaoulidis, Milan Mamtora, Miguel Pineda, Eric S.Fraga, and Panagiota Angeli, Experimental and CFD
scale-up studies for intensified actinide/lanthanide separations, Chemical Engineering and
Processing – Process Intensification, Mar 2021.
Jorge García-Lacuna, Tobias Fleiß, Rachel Munday, Kevin Leslie, Anne O’Kearney-McMullan, Christopher A. Hone, and C.
Oliver Kappe, Synthesis of the Lipophilic
Amine Tail of Abediterol Enabled by Multiphase Flow Transformations, Org. Process
Res. Dev., Mar 2021.
Victor-Emmanuel H. Kassin, Romain Morodo, Thomas Toupy, Isaline Jacquemin, Kristof Van Hecke, Raphaël Robiette,
and Jean-Christophe M. Monbaliu, A modular, low footprint
and scalable flow platform for the expedient α-aminohydroxylation of enolizable ketones,
Green Chemistry, Feb 2021.
Micol Santi, Luca Sancineto, Vanessa Nascimento, Juliano Braun Azeredo, Erika V. M. Orozco, Leandro H. Andrade,
Harald Gröger, and Claudio Santi, Flow Biocatalysis: A
Challenging Alternative for the Synthesis of APIs and Natural Compounds, International Journal of
Molecular Sciences, Jan 2021.
Mellisa B. Sagandira, Cloudius R. Sagandira, and Paul Watts, Continuous flow synthesis of xylidines
via biphasic nitration of xylenes and nitro-reduction, Journal of Flow Chemistry, Jan
2021.
Glen Surjadinata, Luke Hunter, Lidia Matesic, and Giancarlo Pascali, Analytical-scale synthesis of
aryl-SF4Cl via flow microfluidic technology, Journal of Flow Chemistry., Jan 2021.
Samuel J. Miller, Haruro Ishitani, Yuichi Furiya, and Shu̅ Kobayashi, High-Throughput Synthesis of
(S)-α-Phellandrene through Three-Step Sequential Continuous-Flow Reactions, Org. Process Res.
Dev., Jan 2021.
Jillian W. Sheeran, Kiersten Campbell, Christopher P. Breen, Gerald Hummel, Changfeng Huang, Anamika Datta, Serge H.
Boyer, Scott J. Hecker, Matthew M. Bio, Yuan-Qing Fang, David D. Ford, and M. Grace Russell, Scalable On-Demand Production of Purified
Diazomethane Suitable for Sensitive Catalytic Reactions, Org. Process Res. Dev., Jan
2021.
Dimitrios Tsaoulidis, Milan Mamtora, Marta Mayals Gañet,
Eduardo Garciadiego-Ortega, and Panagiota Angeli,
Scale-Up Studies for Co/Ni Separations in Intensified Reactors, Micromachines., Dec
2020.
Hoang Khang Bui, Ki Yoon Kim, Hyeonjin Kim, Jae‐Pyoung Ahn, Taekyung Yu, and Tae Seok Seo, Total Integration of the Sample
Injection, Microdroplet Reaction, Phase Separation, Real‐Time Optical Detection, and Recovery of Diverse
Silver–Gold Bimetallic Nanoalloys in a Continuous Process,Particle., Dec 2020.
Su Wang, Yeersen Patehebieke, Zheng Zhou, Zhibing Zhang, and Xiao Wang, Recent
Advances in Continuous-Flow Reactions Using Metal-Free Homogeneous
Catalysts,Catalysts, Nov 2020.
Piera De Santis, Lars-Erik Meyer, and Selin Kara, The rise of continuous flow
biocatalysis – fundamentals, very recent developments and future perspectives, Reaction Engineering
and Chemistry, Oct 2020.
Naoto Sugisawa, Hiroyuki Nakamura, and Shinichiro Fuse, Catalyst-free biphasic oxidation of
Thiophenes in continuous-flow, Journal of Flow Chemistry, Jul 2020.
Jorge García‐Lacuna, Prof. Dr. Gema Domínguez, and Prof. Dr. Javier Pérez‐Castells, Flow Chemistry for
Cycloaddition Reactions, ChemSusChem, Jul 2020.
Elizabeth Farrant Automation of
Synthesis in Medicinal Chemistry: Progress and Challenges, ACS Med. Chem. Lett., Jul
2020.
Alejandro Mata, Ulrich Weigl, Oliver Flögel, Pius Baur, Christopher A. Hone and C. Oliver Kappe, Acyl azide generation and amide bond
formation in continuous-flow for the synthesis of peptides, React. Chem. & Eng.,
Mar 2020.
Kristina Søborg Pedersen, Christina Baun, Karin Michaelsen Nielsen, Helge Thisgaard, Andreas Ingemann Jensen and
Fedor Zhuravlev, Design,
Synthesis, Computational, and Preclinical Evaluation of natTi/45Ti-Labeled Urea-Based Glutamate PSMA
Ligand, Molecules, Mar 2020.
Peter Sagmeister, Johannes Poms, Jason Williams and C. Oliver Kappe, Multivariate analysis
of inline benchtop NMR data enables rapid optimization of a complex nitration in flow, React. Chem.
& Eng., Feb 2020.
Adam D. Clayton, Luke A. Power, William R. Reynolds, Caroline Ainsworth, David R. J. Hose, Martin F. Jones, Thomas
W. Chamberlain, A. John Blacker & Richard A. Bourne, Self-optimising reactive extractions:
towards the efficient development of multi-step continuous flow processes, Journal of Flow
Chemistry, Feb 2020.
Victor-Emmanuel H. Kassin, Thomas Toupy, Guillaume Petit, Pauline Bianchi, Elena Salvadeo & Jean-Christophe M.
Monbaliu, Metal-free hydroxylation
of tertiary ketones under intensified and scalable continuous flow conditions, Journal of Flow
Chemistry, Feb 2020.
Chetsada Khositanon, Kanyaporn Adpakpang, Sareeya Bureekaew & Nopphon Weeranoppanant, Continuous-flow purification of silver
nanoparticles and its integration with flow synthesis, Journal of Flow Chemistry, Feb
2020.
Govaerts, S., Nyuchev, A. & Noel, T., Pushing the
boundaries of C–H bond functionalization chemistry using flow technology, J Flow Chem,
Feb 2020.
Antimo Gioiello, Alessandro Piccinno, Anna Maria Lozza, and Bruno Cerra, The Medicinal Chemistry in the Era of Machines
and Automation: Recent Advances in Continuous Flow Technology, Journal of Medicinal
Chemistry, Feb 2020.
V Volker Hessel, Nam Nghiep Tran, Sanaz Orandi, Mahdieh Razi Asrami, Michael Evan Goodsite, Hung T. Nguyen,
Continuous-Flow Extraction of
Adjacent Metals – a Disruptive Economic Window for In-Situ Resource Utilization of Asteroids?,
Angewandte Chemie, Jan 2020.
Francesca Tentori, Elisabetta Brenna, Michele Crotti, Giuseppe Pedrocchi‐Fantoni, Maria Chiara Ghezzi and Davide
Tessaro, Continuous‐Flow
Biocatalytic Process for the Synthesis of the Best Stereoisomers of the Commercial Fragrances Leather
Cyclohexanol (4‐Isopropylcyclohexanol) and Woody Acetate (4‐(Tert‐Butyl)Cyclohexyl Acetate),
Catalysts, Jan 2020.
Edith Chow, Burkhard Raguse, Enrico Della Gasper, Steven J. Barrow, Jungmi Hong, Lee J. Hubble, Roger Chai, James S.
Cooper and Andrea Sosa Pintos, Flow-controlled
synthesis of gold nanoparticles in a biphasic system with inline liquid–liquid separation, React.
Chem.Eng., Jan 2020.
Nopphon Weeranoppanant and Andrea Adamo, In-Line Purification: A Key Component to
Facilitate Drug Synthesis and Process Development in Medicinal Chemistry, ACS Med. Chem.
Lett., Dec 2019.
Adam D. Clayton, Artur M.Schweidtmann, Graeme Clemens, Jamie A. Manson, Connor J.Taylor, Carlos G.Niñod Thomas
W.Chamberlain, Nikil Kapur, A. John Blacker, Alexei A.Lapkin, Richard A.Bourne, Automated self-optimisation of
multi-step reaction and separation processes using machine learning, Chemical Engineering
Journal, Nov 2019.
Le Sang, Jiacheng Tu, Han Cheng, Guangsheng Luo, Jisong Zhang, Hydrodynamics and mass transfer of
gas–liquid flow in micropacked bed reactors with metal foam packing, AIChE Journal,
Sep 2019.
Martina Letizia Contente Francesca Paradisi, Transaminase‐catalyzed continuous
synthesis of biogenic aldehydes, ChemBioChem, June 2019.
Martina Letizia Contente, Stefano Farris, Lucia Tamborini, Francesco Molinari, and Francesca Paradisi, Flow-based enzymatic synthesis of
melatonin and other high value tryptamine derivatives: a five-minute intensified process, Green
Chem., May 2019.
Luke Rogers and Klavs F. Jensen, Continuous manufacturing – the Green
Chemistry promise?, Green Chem., May 2019.
Zinia Jaman, Tiago J. P. Sobreira, Ahmed Mufti, Christina R. Ferreira, R. Graham Cooks, and David H. Thompson,
Rapid On-Demand Synthesis of Lomustine under
Continuous Flow Conditionss, Org. Process Res. Dev., Feb 2019.
René Lebl, David Cantillo, and C. Oliver Kappe, Continuous generation, in-line
quantification and utilization of nitrosyl chloride in photonitrosation reactions, React. Chem.
Eng., Jan 2019.
Matthew P. Thompson, Itziar Peñafiel, Sebastian C. Cosgrove, and Nicholas J. Turner, Biocatalysis Using Immobilized Enzymes in
Continuous Flow for the Synthesis of Fine Chemicals, Organic Process Research and
Development, Jan 2019.
Petra Martini, Andrea Adamo, Neilesh Syna, Alessandra Boschi, Licia Uccelli, Nopphon Weeranoppanant, Jack Markham,
and Giancarlo Pascali, Perspectives on the Use of Liquid
Extraction for Radioisotope Purification, Molecules, Jan 2019.
Jenny-Lee Panayides, Darren Lyall Riley, Rachel Chikwamba and Ian Strydom, Landscape and
opportunities for active pharmaceutical ingredient manufacturing in developing African economies,
Reaction Chemistry and Engineering, Jan 2019.
Samir Diab, Nikolaos Mytis, Andreas G.Boudouvis, and Dimitrios I.Gerogiorgis, Process Modelling, Design and
Technoeconomic Liquid-Liquid Extraction (LLE) Optimisation for Comparative Evaluation of Batch vs.
Continuous Pharmaceutical Manufacturing of Atropine,, Computers and Chemical
Engineering, Dec 2018.
Dr. Mathieu Lesieur, Dr. Claudio Battilocchio, Dr. Ricardo Labes, Dr. Jérôme Jac,q Dr. Christophe Genicot, Prof.
Steven V. Ley, and Dr. Patrick Pasau, Direct Oxidation of Csp3−H bonds using
in Situ Generated Trifluoromethylated Dioxirane in Flow, Chemistry, Nov 2018.
Clément Audubert, Alexanne Bouchard, Gary Mathieu, and Hélène Lebel, Chemoselective Synthesis of Amines from Ammonium
Hydroxide and Hydroxylamine in Continuous Flow, The Journal of Organic Chemistry, Oct
2018.
Kristina Søborg Pedersen, Joseph Imbrogno, Jesper Fonslet, Marcella Lusardi, Klavs F. Jensen and Fedor Zhuravlev,
Liquid–liquid
extraction in flow of the radioisotope titanium-45 for positron emission tomography applications,
Reaction Chemistry and Engineering, Oct 2018.
Anne-Catherine Bédard, Andrea Adamo, Kosi C. Aroh, M. Grace Russell, Aaron A. Bedermann, Jeremy Torosian, Brian Yue,
Klavs F. Jensen, and Timothy F. Jamison, Reconfigurable system for automated optimization
of diverse chemical reactions, Science, Sep 2018.
Carlos Mendoza Noémie Emmanuel Carlos Paez Laurent Dreesen Jean-Christophe M. Monbaliu, and Benoît Heinrichs,
Improving Continuous Flow Singlet
Oxygen Photooxygenations with Functionalized Mesoporous Silica Nanoparticles
ChemPhotoChem Aug 2018.
Eric Yu, Hari P R Mangunuru, Nakul S Telang, Caleb J Kong, Jenson Verghese, Stanley E Gilliland III, Saeed Ahmad,
Raymond N Dominey, and B Frank Gupton, High-yielding
continuous-flow synthesis of antimalarial drug hydroxychloroquine, Beilstein J Org
Chem. March 2018.
Hongwei Yang, Benjamin Martin, and Berthold Schenkel, On-Demand Generation and Consumption of
Diazomethane in Multistep Continuous Flow Systems, Organic Process Research &
Development March 2018.
Koichiro Masuda, Tomhohiro Ichitsuka, Nagatoshi Koumura, Kazuhito Sato, Shu Kobayashi, Flow fine synthesis with
heterogeneous catalysts, Tetrahedron Feb 2018.
Gemoets, H. P. L. (2018). Enabling and
accelerating C-H functionalization through continuous-flow chemistry Eindhoven: Technische Universiteit
Eindhoven
Jatuporn Salaklang, Veronique Maes, Matthias Conradi, Rudy Damsb and Tanja Junkers, Direct synthesis of
acrylate monomers in heterogeneous continuous flow processes Reaction Chemistry and
Engineering Dec 2017.
Joshua Britton and Timothy F Jamison, The assembly
and
use of continuous flow systems for chemical synthesis Nature Protocols Oct 2017.
Dr. Martina L. Contente, Federica Dall’Oglio, Dr. Lucia Tamborini, Prof. Francesco Molinari, Prof. Francesca
Paradisi, Highly Efficient Oxidation of Amines to Aldehydes with Flow-based
Biocatalysis
ChemCatChem Sep 2017.
Gabriel Glotz, Rene Lebl, Doris Dallinger, C. Oliver Kappe, Integration of Bromine and Cyanogen Bromide Generators for the Telescoped Continuous
Synthesis of Cyclic Guanidines Angew. Chem. Int. Ed. Sep 2017.
Amanda C. Wicker, Frank A. Leibfarth and Timothy F. Jamison, Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular
macromolecules Polym. Chem. Sep 2017.
Valerio De Vitis, Federica Dall’Oglio, Andrea Pinto, Carlo De Micheli, Francesco Molinari, Paola Conti, Diego
Romano, Lucia Tamborini, Chemoenzymatic Synthesis in Flow
Reactors: A Rapid and Convenient Preparation of Captopril, Chemistry Open July 2017.
Michael R Chapman, Maria H. Kwan, Georgina King, Katherine E Jolley, Mariam Hussain, Shahed Hussain, Ibrahim E
Salama, Carlos González Nino, Lisa A Thompson, Mary E Bayana, Adam Clayton, Bao N. Nguyen, Nicholas J Turner, Nikil
Kapur, and
A. John Blacker, A Simple and Versatile
Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times Org.
Process Res. Dev. June 2017.
Jinu Joseph John, SimonKuhn, Leen Braeken, and Tom Van Gerven, Temperature controlled interval
contact design for ultrasound assisted liquid-liquid extraction Chem. Eng. Res. Des.
June
2017.
Hannes P. L. Gemoets, Gabriele Laudadio, Kirsten Verstraete, Prof. Dr. Volker Hessel, and Dr. Timothy Noël,
A Modular Flow Design for the
meta-Selective C−H Arylation of Anilines Angew. Chem. Int. Ed. May 2017.
Nopphon Weeranoppanant, Andrea Adamo, Galym Saparbaiuly, Eleanor Rose, Christian Fleury, Berthold Schenkel, and
Klavs F. Jensen, Design of Multistage Counter-Current Liquid–Liquid Extraction for Small-Scale
Applications Ind. Eng. Chem. Res. Apr 2017.
Yi Shen, Nopphon Weeranoppanant, Lisi Xie, Yue Chen, Marcella R. Lusardi, Joseph Imbrogno, Moungi G. Bawendi and
Klavs F. Jensen, Multistage extraction platform for highly efficient and fully continuous
purification of nanoparticles Nanoscale Mar 2017.
C. Battilocchio, G. Iannucci, S. Wang, E. Godineau, A. Kolleth, A. De Mesmaeker and S. V. Ley Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and
ethylene gas React. Chem. Eng. Mar 2017.
Joshua Britton and Colin L. Raston, Multi-step continuous-flow synthesis Chem. Soc. Rev. Jan 2017.
David Cantillo, Bernd Wolf, Roland Goetz, and C. Oliver Kappe, Continuous Flow
Synthesis of a Key 1,4-Benzoxazinone Intermediate via a Nitration/Hydrogenation/Cyclization
Sequence Org. Process Res. Dev. Dec 2016.
Hansjoerg Lehmann, A scalable and safe continuous flow procedure for in-line generation of
diazomethane and its precursor MNU. Green Chemistry. Dec 2016.
Maryam Peer, Nopphon Weeranoppanant, Andrea Adamo, Yanjie Zhang, and Klavs F. Jensen, Biphasic catalytic hydrogen peroxide oxidation of alcohols in flow: Scale up and
extraction Org. Process Res. Dev. Aug 2016.
Franz J. Strauss, David Cantillo, Javier Guerrac and C. Oliver Kappe, A laboratory-scale continuous flow chlorine generator for organic synthesis
React. Chem. Eng. Aug 2016.
Baptiste Leforestiera and Markus Vögtle, Safe Generation and Direct Use of Chlorine Azide in Flow Chemistry: 1,2-Azidochlorination of
Olefins and Access to Triazoles Synlett. June 2016.
Andrea Adamo, Rachel L. Beingessner, Mohsen Behnam, Jie Chen, Timothy F. Jamison, Klavs F. Jensen, Jean-Christophe
M. Monbaliu, Allan S. Myerson, Eve M. Revalor, David R. Snead, Torsten Stelzer, Nopphon Weeranoppanant, Shin Yee
Wong, Ping Zhang, On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable
system
Science April 2016.
L Osorio-Planes, C Rodríguez-Escrich, MA Pericas, Removing the superfluous: a supported squaramide catalyst with a minimalistic linker
applied to the enantioselective flow synthesis of pyranonaphthoquinones Catalysis
Science & Technology Mar 2016.
Lorenzo Di Marco, Dr. Morgan Hans, Prof. Lionel Delaude and Dr. Jean-Christophe M. Monbaliu, Continuous-Flow N-Heterocyclic Carbene Generation and Organocatalysis
Chem. Eur. J. Feb 2016.
Javier Guerra, David Cantillo and C Oliver Kappe, Visible-Light Photoredox Catalysis using a Macromolecular Ruthenium Complex: Reactivity
and Recovery by Size-Exclusion Nanofiltration in Continuous Flow Catal. Sci.
Technol. Feb 2016.
Nicolas Lamborelle, Justine F Simon, Andre LUXEN and Jean-Christophe Monbaliu, Continuous-Flow Thermolysis for the Preparation of Vinylglycine Derivatives
Org. Biomol. Chem. Nov 2015.
Irina Sagamanova, Carles Rodríguez-Escrich, István Gábor Molnár, Sonia Sayalero, Ryan Gilmour, and Miquel A.
Pericàs, Translating the Enantioselective Michael Reaction to a Continuous Flow Paradigm with an
Immobilized, Fluorinated Organocatalyst ACS Catal. Sept 2015.
Leibfarth FA, Johnson JA, and Jamison TF, Scalable synthesis of sequence-defined, unimolecular macromolecules by
Flow-IEG
Proc. Natl. Acad. Sci. Aug 2015.
Chunhui Dai, David R. Snead, Ping Zhang, and Timothy F. Jamison, Continuous-Flow Syn and Purification of
Atropine with Sequential In-Line Separations of Structurally Similar Impurities J.
Flow Chem. July 2015.
Steffen Glöckner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio and Steven V.
Ley,
The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under
flow conditions Org. Biomol. Mol. Oct 2014.
Trevor A. Hamlin, Gillian M. L. Lazarus, Christopher B. Kelly, and Nicholas E. Leadbeater, A Continuous-Flow Approach to 3,3,3-Trifluoromethylpropenes:
Bringing Together Grignard Addition, Peterson Elimination, Inline Extraction, and Solvent
Switching. Org. Process Res. Dev. Aug 2014.
Andrea Adamo, Patrick L Heider, Nopphon Weeranoppanant, and Klavs F. Jensen, Membrane-Based, Liquid-Liquid Separator with Integrated
Pressure Control. Ind. Eng. Chem. Res. July 2013.
Gas-Liquid Separation
Gas-Liquid Separation
Jisong Zhang, Andrew R. Teixeira, Lars Thilo Kögl, Lu Yang, and Klavs F. Jensen Hydrodynamics of gas–liquid flow in
micropacked beds: Pressure drop, liquid holdup, and two-phase model AIChE
Journal June 2017.
Everett J. O’Neal, Chang Ho Lee, Julian Brathwaite, and Klavs F. Jensen, Continuous Nanofiltration and Recycle of an
Asymmetric Ketone Hydrogenation Catalyst ACS Catal. March 2015.
Reference to separator’s theory:
Kralj, J. G.; Sahoo, H. R.; Jensen, K. F., Integrated continuous microfluidic liquid-liquid extraction.
Lab Chip.2007, 7, (2), 256-263.
Reference to examples of use of liquid–liquid separators:
Sahoo, H. R.; Kralj, J. G.; Jensen, K. F., Multistep Continuous-Flow Microchemical Synthesis Involving Multiple
Reactions and Separations. Angew. Chem. Int. Ed. 2007, 46, (30), 5704-5708.
Cervera-Padrell, A. E.; Morthensen, S. T.; Lewandowski, D. J.; Skovby, T.; Kiil, S.; Gernaey, K. V., Continuous
Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale
Hydrophobic Membrane Separator. Org. Process Res. Dev. 2012, 16, (5), 888-900.
Multistage Extraction
C. Heiduk, I. Hohlen, and S. Scholl, Multi-Stage Liquid/Liquid Extraction with a Zaiput Apparatus, SPhERe – 4rd International Symposium on Pharmaceutical Engineering Research, 15. – 17. Sept 2021.
Nopphon Weeranoppanant and Andrea Adamo, In-Line Purification: A Key Component to
Facilitate Drug Synthesis and Process Development in Medicinal Chemistry, ACS Med. Chem.
Lett., Dec 2019.
René Lebl, Trevor Murray, Andrea Adamo, David Cantillo, C. Oliver Kappe, Continuous Flow
Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid-Liquid
Extraction and Membrane Separation Technology, ACS Sustainable Chem. Eng., Nov 2019.
Scientific research articles relating to our multistage extraction platform:
Nopphon Weeranoppanant, Andrea Adamo, Galym Saparbaiuly, Eleanor Rose, Christian Fleury, Berthold Schenkel, and Klavs F.
Jensen, Design of
Multistage Counter-Current Liquid–Liquid Extraction for Small-Scale Applications Ind. Eng. Chem.
Res. Apr 2017.
Yi Shen, Nopphon Weeranoppanant, Lisi Xie, Yue Chen, Marcella R. Lusardi, Joseph Imbrogno, Moungi G. Bawendi and Klavs
F. Jensen, Multistage extraction platform for highly efficient and fully continuous
purification of nanoparticles Nanoscale Mar 2017.
Maryam Peer, Nopphon Weeranoppanant, Andrea Adamo, Yanjie Zhang, and Klavs F. Jensen, Biphasic catalytic hydrogen peroxide oxidation of alcohols in flow: Scale up and extraction
Org. Process Res. Dev. Aug 2016.
Pressure Regulation
Scientific articles featuring our back pressure regulators:
Federico Florit, Anirudh M. K. Nambiar, Christopher P. Breen, Timothy F. Jamison, and Klavs F. Jensen, Design of dynamic trajectories for efficient and data-rich exploration of flow reaction design spaces, React. Chem. Eng., Sept 2021.
Michaela Wernik, Gellért Sipos, Balázs Buchholcz, Ferenc Darvas, Zoltán Novák, Sándor B. Ötvös, and C. Oliver Kappe, Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions enabled by an oscillatory plug flow reactor, Green Chemistry, July 2021.
Baldassarre Venezia, Luca Panariello, Daniel Biri, Juhun Shin, Spyridon Damilos, Anand N.P. Radhakrishnan, Chris Blackman, Asterios Gavriilidis, Catalytic Teflon AF-2400 membrane reactor with adsorbed ex situ synthesized Pd-based nanoparticles for nitrobenzene hydrogenation, Catalysis Today, Feb 2021.
Victor-Emmanuel H. Kassin, Romain Morodo, Thomas Toupy, Isaline Jacquemin, Kristof Van Hecke, Raphaël Robiette, and Jean-Christophe M. Monbaliu, A modular, low footprint and scalable flow platform for the expedient α-aminohydroxylation of enolizable ketones, Green Chemistry, Feb 2021.
Hoang Khang Bui, Ki Yoon Kim, Hyeonjin Kim, Jae‐Pyoung Ahn, Taekyung Yu, and Tae Seok Seo, Total Integration of the Sample Injection, Microdroplet Reaction, Phase Separation, Real‐Time Optical Detection, and Recovery of Diverse Silver–Gold Bimetallic Nanoalloys in a Continuous Process, Particle., Dec 2020.
Ke Wu, Gaowei Wu, Alexander J. MacRobert, Elaine Allan, Asterios Gavriilidis, and Ivan P. Parkin, Ultra high molecular weight polyethylene with incorporated crystal violet and gold nanoclusters is antimicrobial in low intensity light and in the dark, Mater. Adv.., Nov 2020.
Gi Byoung Hwang, Gaowei Wu, Juhun Shin, Luca Panariello, Victor Sebastian, Kersti Karu, Elaine Allan, Asterios Gavriilidis, and Ivan P. Parkin, Continuous Single-Phase Synthesis of [Au25(Cys)18] Nanoclusters and their Photobactericidal Enhancement, ACS Appl. Mater. Interfaces, Oct 2020.
Elena Herrero-Gomez, Cornelis H. M. van der Loo, Lena Huck, Ana Rioz-Martínez, Nandell F. Keene, Bryan Li, Kees Pouwer, Christophe Allais, Photo-oxidation of Cyclopentadiene Using Continuous Processing: Application to the Synthesis of (1R,4S)-4-Hydroxycyclopent-2-en-1-yl Acetate, Org. Process Res. Dev., April 2020.
Cristian Rosso, Sebastian Gisbertz, Jason D. Williams, Hannes P. L. Gemoets, Wouter Debrouwer, Bartholomäus Pieber and C. Oliver Kappe, An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings, Reaction Chemistry and Engineering, Feb 2020.
Romaric Gérardy, Julien Estager, Patricia Luis, Damien P. Debeckerd and Jean-Christophe M. Monbaliu, Versatile and scalable synthesis of cyclic organic carbonates under organocatalytic continuous flow conditions, Catalysis Science & Technology, Jan 2020.
Baldassarre Venezia, Mark Douthwaite, Gaowei Wu, Meenakshisundaram Sankar, Peter Ellis, Graham J.Hutchings, Asterios Gavriilidis, Slurry loop tubular membrane reactor for the catalysed aerobic oxidation of benzyl alcohol, Chemical Engineering Journal, Dec 2019.
He Huang, Gi Byoung Hwang, Gaowei Wu Kersti Karu, Hendrik Du Toit, Han Wu, June Callison, Ivan P. Parkin, Asterios Gavriilidis, Rapid synthesis of [Au25(Cys)18] nanoclusters via carbon monoxide in microfluidic liquid-liquid segmented flow system and their antimicrobial performance, Chemical Engineering Journal, Oct 2019.
Róbert Örkényi1, Continuous Purifications in Multistep Continuous Flow Synthesis of Pharmaceutical Compounds, Poster Presentation, Sep 2019.
Anna Pekkari, Zafer Say, Arturo Susarrey-Arce, Christoph Langhammer, Hanna Härelin, Victor Sebastian, Kasper Moth-Poulsen, Continuous Microfluidic Synthesis of Pd Nanocubes and PdPt Core–Shell Nanoparticles and Their Catalysis of NO2 Reduction, ACS Appl. Mater. Interfaces, Aug 2019.
Alexander Steiner Jason D. Williams Juan A Rincón Oscar de Frutos Carlos Mateos C. Oliver Kappe, Implementing Hydrogen Atom Transfer (HAT) Catalysis for Rapid and Selective Reductive Photoredox Transformations in Continuous Flow, European Journal of Organic Chemistry, July 2019.
C Rosso, JD Williams, G Filippini, M Prato, CO Kappe, Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate, Organic Letters, June 2019.
Gaowei Wu, Enhong Cao, Peter Ellis, Achilleas Constantinou, Simon Kuhn, Asterios Gavriilidis, Continuous flow aerobic oxidation of benzyl alcohol on Ru/Al2O3 catalyst in a flat membrane microchannel reactor: An experimental and modelling study, Chemical Engineering Science, Volume 201, 29 June 2019, Pages 386-396.
Conor Waldron, Arun Pankajakshan, Marco Quaglio, Enhong Cao, Federico Galvanin, and Asterios Gavriilidis, An autonomous microreactor platform for the rapid identification of kinetic models, React. Chem. Eng., April 2019.
Victor-Emmanuel Horst Kassin, Romaric Gérardy, Thomas Toupy, Diégo Collin, Elena Salvadeo, François Toussaint, Kristof Van Hecke and Jean-Christophe M Monbaliu Expedient Preparation of Active Pharmaceutical Ingredient Ketamine under Sustainable Continuous Flow Conditions, Green Chemistry, March 2019.
René Lebl, David Cantillo, and C. Oliver Kappe, Continuous generation, in-line quantification and utilization of nitrosyl chloride in photonitrosation reactions, React. Chem. Eng., Jan 2019.
Jason D. Williams, Momoe Nakano, Romaric Gérardy, Juan A. Rincón, Óscar de Frutos, Carlos Mateos, Jean-Christophe M. Monbaliu, and C. Oliver Kappe, Finding the Perfect Match: A Combined Computational and Experimental Study toward Efficient and Scalable Photosensitized [2 + 2] Cycloadditions in Flow, Organic Process Research and Development Jan 2019.
Chengwen Xue, Jiesheng Li, Jin Ping Lee, Ping Zhang and Jie Wu, Continuous amination of aryl/heteroaryl halides using aqueous ammonia in a Teflon AF-2400 tube-in-tube micro-flow reactor, Reaction Chemistry and Engineering November 2018.
Manuel Köckinger, Christopher A. Hone, Bernhard Gutmann, Paul Hanselmann, Michael Bersier, Ana Torvisco, and C. Oliver Kappe, Scalable Continuous Flow Process for the Synthesis of Eflornithine Using Fluoroform as Difluoromethyl Source, Org. Process Res. Dev. November 2018.
Zhiguo Wang, Romaric Gérardy, Guillaume Gauron, Christian Damblon and Jean-Christophe M Monbaliu, Solvent-free organocatalytic preparation of cyclic organic carbonates under scalable continuous flow conditions, Reaction Chemistry & Engineering Oct 2018.
Irini Abdiaj, Clemens R. Horn, and Jesus Alcazar, Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR Monitoring, The Journal of Organic Chemistry Oct 2018.
Gaowei Wu, Enhong Cao, Peter Ellis, Achilleas Constantinou, Simon Kuhn, Asterios Gavriilidis, Development of a flat membrane microchannel packed-bed reactor for scalable aerobic oxidation of benzyl alcohol in flow, Chemical Engineering Journal Oct 2018.
Nelly Ntumba Tshibalonza, Romaric Gérardy, Zouheir Alsafra, Gauthier Eppeb and Jean-Christophe M. Monbaliu,
A versatile biobased continuous flow strategy for the production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol, Green Chemistry Sep 2018.
Carlos Mendoza Noémie Emmanuel Carlos Paez Laurent Dreesen Jean-Christophe M. Monbaliu, and Benoît Heinrichs, Improving Continuous Flow Singlet Oxygen Photooxygenations with Functionalized Mesoporous Silica Nanoparticles, ChemPhotoChem Aug 2018.
Nathalie Ollivier, Thomas Toupy, Ruben C. Hartkoorn, Rémi Desmet, Jean-Christophe M. Monbaliu & Oleg Melnyk, Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides, Nature Communications July 2018.
Carlos Mendoza, Noémie Emmanuel, Carlos Alberto Páez, Laurent Dreesen, Jean-Christophe M. Monbaliu, Benoît Heinrichs, Transitioning from conventional batch to microfluidic processes for the efficient singlet oxygen photooxygenation of methionine, J. Photochemistry Dec 2017.
Joshua Britton and Timothy F Jamison, The assembly and use of continuous flow systems for chemical synthesis , Nature Protocols Oct 2017.
Amanda C. Wicker, Frank A. Leibfarth and Timothy F. Jamison, Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules, Polym. Chem. Sep 2017.
Gaowei Wu, Enhong Cao, Simon Kuhn, and Asterios Gavriilidis, A Novel Approach for Measuring Gas Solubility in Liquids Using a Tube-in-Tube Membrane Contactor, Chem. Eng. Technol. Aug 2017.
Róbert Örkényi, Gyula Beke, Eszter Riethmüller, Zoltán Szakács, János Kóti, Ferenc Faigl, János Éles, and István Greiner, Environment-Friendly Synthesis of Indoline Derivates Using Flow Chemistry Techniques, Eur. J. Org. Chem. Aug 2017.
Paul Watts and Cloudius Sagandira, Synthesis of amines, carbamates and amides via multi-step continuous flow synthesis , Eur. J. Org. Chem. Aug 2017.
Noémie Emmanuel, Carlos Mendoza, Marc Winter, Clemens R. Horn, Alessandra Vizza, Laurent Dreesen, Benoît Heinrichs, and Jean-Christophe M. Monbaliu, Scalable Photocatalytic Oxidation of Methionine under Continuous-Flow Conditions Org. Process Res. Dev. July 2017.
Isabel Ortiz de Solorzano, Martin Prieto, Gracia Mendoza, Teresa Alejo, Silvia Irusta, Manuel Arruebo, and Victor Sebastian, Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulphide Nanoparticles ACS Appl. Mater. Interfaces Aug 2016.
Maryam Peer, Nopphon Weeranoppanant, Andrea Adamo, Yanjie Zhang, and Klavs F. Jensen, Biphasic catalytic hydrogen peroxide oxidation of alcohols in flow: Scale up and extraction Org. Process Res. Dev. Aug 2016.
Andrea Adamo, Rachel L. Beingessner, Mohsen Behnam, Jie Chen, Timothy F. Jamison, Klavs F. Jensen, Jean-Christophe M. Monbaliu, Allan S. Myerson, Eve M. Revalor, David R. Snead, Torsten Stelzer, Nopphon Weeranoppanant, Shin Yee Wong, Ping Zhang, On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system Science April 2016.
Achilleas Constantinou, Gaowei Wu, Albert Corredera, Peter Ellis, Donald Bethell, Graham J. Hutchings, Simon Kuhn, and Asterios Gavriilidis, Continuous Heterogeneously Catalyzed Oxidation of Benzyl Alcohol in a Ceramic Membrane Packed-Bed Reactor Organic Process Research & Development December 2015.
Chunhui Dai, David R. Snead, Ping Zhang, and Timothy F. Jamison, Continuous-Flow Syn and Purification of Atropine with Sequential In-Line Separations of Structurally Similar Impurities J. Flow Chem. July 2015.
David Snead, Timothy Jamison, A Three‐Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous‐Flow Processing. AngewandteChemie, Dec 2014.