Continuous Synthesis of Warfarin with Zaiput BPR
Continuous setup for the synthesis of Warfarin
An insightful paper written by the researchers at FloW4all Flow Technology Resource Center of University of Liège, with the researchers at University of Puerto Rico. Warfarine, one of the drugs part of the World Health Organization’s list of essential medicines, is typically synthesized in batch with low yield in a very slow process, where production take days.
A Flow Chemistry approach, as demonstrated in the paper, has the potential to boost yield and reduce processing times, resulting in a lowered estimated cost for the patient.
A Zaiput Back Pressure Regulator is used to maintain the reaction pressure setpoint with accuracy and continuously.
Zaiput Back Pressure Regulator
Zaiput’s BPR are appreciated for their high precision, great chemical compatibility, broad range of flow rates and continued high performance even in the presence of light solid loading.
Some of their main features are:
- Metal-free wetted parts
- Maximum pressure: 2 MPa (290 psi)
- Very accurate and precise (1%)
Error < 1% across flow rates of 0-1000ml/min - Adjustable set point
Users can simply set any pressure for the BPRs by adjusting the pressure of the compressed air chamber - Excellent for gas-liquid streams
Zaiput’s BPRs are designed to function with a stream containing gas, liquid, or multiphase. - Robust to clogging
Our devices eliminate extremely small orifices, which can cause clogging and over-pressurizing.
Their reliability and accuracy make these BPR a very popular tool in flow chemistry labs around the world.
How the BPR works
Zaiput’s BPRs have a chamber that the user fills with compressed air. The pressure of the inputted air represents the back pressure set point of the device. An elastic sheet intercepts the process fluid flow path and allows a comparison of the pressure of the process fluid to the reference pressure. In other words, the process fluid can flow through the device only when its pressure is equal to the reference pressure.
