Continuous Preparation of Trifluoromethyl Diazomethane in Flow Using In-Line Membrane Phase Separation
THE PAPER
This remarkable paper presents a novel method for the generation of dry, acid-free concentrated solutions of Trifluoromethyl diazomethane (TFDM), a versatile reagent in organic synthesis and medicinal chemistry. A chiral catalyst was utilized to access a variety of enantioenriched trans-trifluoromethyl-substituted cyclopropanes and conversion in flow rather than batch results in an overall safer process. The paper also cites the ease of scale-up of the separators to be an advantage of the reaction scheme overall.
ZAIPUT SEPARATORS
Zaiput’s phase separators are used in the industry for laboratory, pilot and production-scale applications. Researchers in labs around the globe use our membrane based technology to continuously separate bi-phasic mixtures (typically aqueous organic) in industries ranging from Pharma, to Flavor & Fragrances, to Fine Chemicals, and beyond.
The accuracy of the phase separation, the lack of any moving parts, the ability to work without density difference between phases, and the low internal volume, make this device a very common solution for in-line phase separation in flow chemistry labs and continuous manufacturing plants around the world, as shown here.
